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Effects of Sodium Butyrate on the Intestinal Morphology and DNA-Binding Activity of Intestinal Nuclear Factor-?B in Weanling Pigs

Author(s): Zheng-Shun Wen | Jian-Jun Lu | Xiao-Ting Zou

Journal: Journal of Animal and Veterinary Advances
ISSN 1680-5593

Volume: 11;
Issue: 6;
Start page: 814;
Date: 2012;
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Keywords: Sodium butyrate | intestinal morphology | binding activity

A total of 96 pigs weaned at day 21 (Duroc x Landrace x Yorkshire) with an average initial body weight of 6.42 kg were used to investigate the effects of sodium butyrate on growth performance, intestinal morphology and DNA-binding activity of Nuclear Factor-?B (NF-?B) in the small intestine. The pigs were allocated to three dietary treatments in a randomized complete block design. Each treatment was replicated four times with eight pigs per replicate and the trial lasted for 21 days. The dietary treatments were: basal diet, basal diet+500 mg kg-1 sodium butyrate basal diet+1000 mg kg-1 sodium butyrate. The results showed that supplementation with 1000 mg kg-1 sodium butyrate in diets improved (p
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