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Effects Of Treatment With Radioactive Iodine On Gonadal Functions In Patients With Differentiated Thyroid Cancer

Author(s): Fard Esfahani A | Eftekhari M | Aliyari Zenooz N | Saghari M

Journal: Tehran University Medical Journal
ISSN 1683-1764

Volume: 62;
Issue: 1;
Start page: 36;
Date: 2004;
Original page

Keywords: follicular thyroid carcinoma | papillary thyroid carcinoma

Background: The purpose of this study was to evaluate the effect of treatment with radioactive iodine on the function of gonads in males and females with follicular and papillary thyroid carcinoma. Materials and Methods: Consenting patients in the reproductive age were grouped according to the cumulative dose of received radioiodine and followed for at least 12 months. For all men, serum levels of FSH, LH, and testosterone were measured; some (53 cases) were also studied by semen analysis. For women, tests for serum levels of LH, FSH, estrogen, and progesterone were performed. Results: Overall, 246 patients (159 females, 87 males) were studied. In 87.4% of men, there was an increase in serum FSH level after radioiodine therapy, in 20.7% of whom the level remained high during follow-up period. The average serum level of FSH after each course of treatment was significantly higher than the level before treatment (p
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