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Effects of Turnera ulmifolia (Linn.) Leaves on Blood Glucose Level in Normal and Alloxan-Induced Diabetic Rats

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Author(s): D. Prabu | M. Nappinnai | K. Ponnudurai | A. Thirugnanasambanthan | S. Srinivasan | M. Ramvikas

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 8;
Issue: 2;
Start page: 77;
Date: 2009;
Original page

Keywords: Turnera Ulmifolia | Euglycemic | Antihyperglycemic | Alloxan-Induced Diabetes | Rats

ABSTRACT
The methanolic extract of leaves of Turnera ulmifolia L was evaluated for its effect on blood glucose in alloxan-induced diabetic and euglycemic rats. The extract were administered at three doses of 100, 200 and 400 mg/kg, p.o. Glibenclamide (10 mg/kg, p.o.) was used as standard for control group. In euglycemic rat, extract were administered at three doses of 100, 200 and 400 mg/kg, p.o. Extract at 400 mg/kg and glibenclamide significantly reduced blood glucose level in normal and alloxan-induced diabetic rats and raised the liver glycogen content significantly. This indicates that the leaves extract of Turnera ulmifolia L posses anti-hyperglycemic activity.
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