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The Effects of Two Novel Copper-Based Formulations on Helicobacter pylori

Author(s): Ilaria M. Saracino | Cristina Zaccaro | Giovanna Lo Re | Dino Vaira | John Holton

Journal: Antibiotics
ISSN 2079-6382

Volume: 2;
Issue: 2;
Start page: 265;
Date: 2013;
Original page

Keywords: bactericidal | copper | helicobacter | novel formulation

We investigated the effects of two novel copper-based inorganic formulations for their activity against 60 isolates of Helicobacter pylori (Hp). The two copper-based formulations were tested against three NCTC Helicobacter pylori isolates and 57 clinical strains isolated from the UK and Italy in time-kill assays. Both copper-based formulations were bio-cidal against all Helicobacter pylori strains tested reducing the viable count by 4–5 log within 2 h. These two copper-based anti-microbial agents deserve further study in relation to the treatment of H. pylori-related gastric disease.
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