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Effects of urethane and sodium nitrite on different tissues of mice

Author(s): F Koohdani | F Sasani | K Mohammad | P Mehdipour

Journal: Journal of School of Public Health and Institute of Public Health Research
ISSN 1735-7586

Volume: 6;
Issue: 1;
Start page: 47;
Date: 2008;
Original page

Keywords: Sodium nitrite | Urethane | Carcinogenicity | Mice

Background and Aim: To determin the most sensitive tissues to carcinogenic effect of urethane and co-carcinogenic effect of sodium nitrite by investigation of histopathological variations in different tissues of balb/c mice."nMaterials and Methods: An experimental study in 40 inbred balb/c mice aged 9-11 weeks was designed. The samples were classified into 4 groups: The first group was mice treated with 50 mg/l sodium nitrite in 0.9% NaCl instead drinking water SN&NaCl). The urethane group (U) was characterized by intraperitoneal injection of 3 times urethane (600 mg/ kg/day at 48 hour intervals). The third group was given 50 mg/l sodum nitrite in drinking water (U&SN) following the same intake of urethane as the second group, and the forth one was the control group. All mice were sacrificed after 20 weeks; tissues were removed and examined for histopathological changes. Data analyzed by Fisher exact test."nResults: The formation of lung tumor was, significantly, increased in the urethane group as compared with the control group & (NS+Nacl) groups ( respectively P

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