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THE EFFECTS OF VERAPAMIL ON SODIUM AND POTASSIUM SERUM CONCENTRATION AND HE COLORING MORPHOLOGICAL CHANGES IN EXPERIMENTAL GENTAMICIN NEPHROTOXICITY

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Author(s): Milan Ciric | Slavimir Veljkovic | Mirjana Radenkovic | Snezana Cekic | Dragana Velickovic | Milkica Nesic | Suzana Brankovic | Boris Djindjic

Journal: Acta Medica Medianae
ISSN 0365-4478

Volume: 43;
Issue: 2;
Start page: 9;
Date: 2004;
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Keywords: verapamil | protective factor | HE coloring | gentamicin nephrotoxicity

ABSTRACT
The effects of verapamil on glomerular changes and tubular system in rats were analyzed in gentamicin nephrotoxicity. Epithel desquamation of proximal tubules and degenerative changes in glomerular was detected in animals treated by gentamicin (100 mg/kg body mass/24h). In animals, treated by gentamicin, the decreasing of sodium and potassium appeared in comparison to the control group. The combination of verapamil and gentamicin resulted in lower kidney damage than gentamicin itself, so the level of sodium concentration in serum and potassium concentration was higher in the third experimental group. Nephron morphological changes were lower by simultaneous treatment of gentamicin and verapamil. Consequently, the obtaind results support hypothesis that verapamil is a protective factor in gentamicin nephrotoxicity.
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