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The effects of vitamin-E on oxidative stress and metabolic imbalance induced by acute unilateral ureteral obstruction in anaesthetized rats

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Author(s): Ashtiyani SC | Moosavi SMS | Hosseinkhani S | Shirazi M

Journal: Tehran University Medical Journal
ISSN 1683-1764

Volume: 66;
Issue: 9;
Start page: 617;
Date: 2008;
Original page

Keywords: Obstructive nephropathy | vitamin E | stress oxidative | metabolism | rat

ABSTRACT
"nBackground: Obstructive nephropathy has been associated with disorders in metabolism state and oxidative balance of kidney. Stress oxidative play a key role in the pathophysiological processes of renal diseases. The objective of this study was to investigate effects of vitamin-E, as a powerful antioxidant, on renal oxidative stress and metabolism defect induced by 24-hr unilateral ureteral obstruction (UUO). "nMethods: Anesthetized male Sprague-Dawley rats (n=10 in each group) were sterilely operated to occlude the left ureter. In UUO+NS, we had a single dose normal saline injection and in UUO+VitE and UUO+OO groups, D-α-tocopherol (50 mg/kg), the main component of vitamin-E, and its vehicle (Olive Oil), respectively, were twicely infused I.P. before and after UUO-induction. There were also sham-operated and control groups. 24-hr after of UUO-induction, both kidneys were removed and stored in -70°C. To determine metabolism condition, the levels of ATP and ADP; and to evaluate redox state, the levels of malondialdehyde (MDA) and ferric reducing/antioxidant power (FRAP) of kidneys were assessed. "nResults: The comparisons between UUO+NS and sham groups indicated that UUO increased MDA (p
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