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Effects of Vitamin E and Zinc Supplementation on Antioxidants in Beta-Thalassemia Major Patients

Author(s): Mohammadreza Rashidi | Maryam Aboomardani | Maryam Rafraf | Seyed-Rafie Arefhosseini Arefhosseini | Abbasali Keshtkar | Hamidreza Joshaghani

Journal: Iranian Journal of Pediatrics
ISSN 2008-2142

Volume: 21;
Issue: 1;
Start page: 8;
Date: 2011;
Original page

Keywords: Vitamin E | Zinc | Glutathione Peroxidase | Superoxide Dismutase | Body Mass Index | Antioxidants

Objective: In beta thalassemic patients, tissue damage occurs due to oxidative stress and it happens because of the accumulation of iron in the body. This study was conducted to determine the effect of zinc and vitamin E supplementation on antioxidant status in beta-thalassemic major patients. Methods: This double blind randomized clinical trial was carried out on 120 beta thalassemic patients older than 18 years. Patients were randomly categorized in four groups. Zinc (50mg/day) and vitamin E (400mg/day) supplements were administered for former and latter group, respectively. In the third group both supplements were administered in similar doses. The fourth (control) group received no supplement. The effect of supplementations on serum zinc and vitamin E, superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC) and body mass index (BMI) were measured at the beginning and the end of the study. Findings: Serum zinc levels in group 1 and 3 were significantly increased (P
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