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The Efficacy of Intra-Articular Injection of Hyaluronic Acid With Supplemental Peroral Vitamin E Following Arthroscopic Debridement in the Treatment of Knee Osteoarthritis: A Prospective, Randomized, Controlled Study

Author(s): Ahmet Aslan | Vecihi Kırdemir | Tolga Atay | Yakup Barbaros Baykal | Özgür Aytekin | Fazıl Cüneyt Aydoğan

Journal: Türkiye Fiziksel Tip ve Rehabilitasyon Dergisi
ISSN 1302-0234

Volume: 58;
Issue: 3;
Start page: 199;
Date: 2012;
Original page

Keywords: Arthroscopic debridement | knee osteoarthritis | hylan G-F 20 | intra-articular hyaluronic acid | vitamin E

Objective: We evaluated clinical results of intra-articular injection of hyaluronic acid and peroral Vitamin E treatment after arthroscopic debridement in patients with knee osteoarthritis who got no cure with medical treatment previously. Materials and Methods: A total of 44 patients with knee pain, who were diagnosed as having knee osteoarthritis according to the American College of Rheumatology criteria, were included in this study. The subjects were randomly divided into 3 groups after arthroscopic debridement: Group S was given intra-articular Hylan G-F 20 treatment; Group S+E - intraarticular Hylan G-F 20 treatment plus oral vitamin E; and Group C underwent only arthroscopic debridement. Pain, stiffness and functional capacity scores were evaluated preoperatively and 6 and 12 months postoperatively according to the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Results: In all groups, 6- and 12-month postoperative WOMAC scores were lesser than the preoperative ones. The WOMAC scores at 6 and 12 months were statistically lower in the S+E and S groups than in the group C (p
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