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Efficacy of low dose intravenous immunoglobulins in children with toxic epidermal necrolysis: An open uncontrolled study

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Author(s): Mangla Kanu | Rastogi Swati | Goyal Puneet | Solanki Rekha | C Ranjan

Journal: Indian Journal of Dermatology, Venereology and Leprology
ISSN 0378-6323

Volume: 71;
Issue: 6;
Start page: 398;
Date: 2005;
Original page

Keywords: Toxic epidermal necrolysis | Intravenous immunoglobulins

ABSTRACT
Background: High dose intravenous immunoglobulins (IVIG) have emerged as a promising new therapy for treating the rare but potentially fatal drug reaction toxic epidermal necrolysis (TEN). Experimental in vitro studies support the view that IVIG can block the fas-fas ligand mediated apoptosis in TEN. Methods: Ten pediatric patients of TEN were treated with IVIG (0.05 - 0.1 gm/kg/day) along with antibiotics and supportive care. Results: Patients with 67% of mean body surface area of involvement showed an average of 2.1 days for arrest of progression of lesions and 8.1 days for complete reepithelization. There was no mortality. Conclusions: Low dose IVIG appears to be a safe and effective treatment for TEN in children. Randomized trials are needed to further evaluate the efficacy of IVIG and compare it with other therapeutic modalities.
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