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The Efficacy of Topical Glucosamine Sulfate-Chondroitin Sulfate in Knee Osteoarthritis Treated With Physical Therapy: A Randomized, Double-Blind, Placebo-Controlled Study

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Author(s): Belgin Erhan | Berrin Gündüz | Seçil Hıncal Üstünel | Ayşe Nur Bardak | Ferdi Yavuz | Gülsün Iska | Zuhal Karakoyun

Journal: Türkiye Fiziksel Tip ve Rehabilitasyon Dergisi
ISSN 1302-0234

Volume: 58;
Issue: 3;
Start page: 194;
Date: 2012;
Original page

Keywords: Glucosamine | knee osteoarthritis | physical therapy | WOMAC

ABSTRACT
Objective: To determine the efficacy of topical glucosamine on pain and functional status in patients receiving physical therapy for knee osteoarthritis (OA).Materials and Methods: Forty-nine patients with knee OA were randomized into two groups. The first group consisted of 27 patients receiving physical therapy and topical glucosamine and the second group consisted of 22 patients receiving physical therapy and placebo, for 4 weeks. The patients and the physician were blinded to the treatment. The patients were evaluated before the treatment and at 1, 4, and 12 weeks. Demographic features, pain duration and radiological findings (Kellgren-Lawrence) were recorded; joint stiffness and physical function were evaluated by the Western Ontario and McMaster Osteoarthritis Index (WOMAC). Results: The WOMAC scores for pain, stiffness, and function were significantly improved in both groups at 1 and 4 weeks as compared to the pre-treatment period (P0.05). Conclusion: In this study, it was shown that topical glucosamine treatment combined with physical therapy in patients with knee OA had no superiority over placebo. Turk J Phys Med Re­hab 2012;58:194-8.
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