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Efficacy of Transarterial Chemoembolization on Lesion Reduction in Colorectal Liver Metastases

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Author(s): Hossein Ghanaati | Vahid Mohammadzadeh | Ali Mohammadzadeh | Kavous Firouznia | Maryam Mohammadzadeh | Marzieh Motevali | Sakineh Kadivar | Mohammad Ali Mohammadzadeh | Abbas Dargahi | Amir Hossein Jalali | Madjid Shakiba | Payam Azadeh

Journal: Acta Medica Iranica
ISSN 0044-6025

Volume: 50;
Issue: 8;
Start page: 535;
Date: 2012;
Original page

Keywords: Colorectal carcinoma | Liver metastases | Transarterial chemoembolization | Chemotherapy

ABSTRACT
Following failure of systemic chemotherapy, transarterial chemoembolization (TACE) is an available method to control unresectable liver metastases from colorectal carcinoma (CRC). The aim of present study was to evaluate the efficacy of chemoembolization for inoperable metastatic liver lesions from CRC. Forty-five CRC patients with liver metastases resistant to systemic chemotherapy were enrolled in our study. For each patient, three session of TACE were conducted with 45 days interval. A combination of mitomycin, doxorubicin, and lipiodol were used for TACE. A tri-phasic computed tomography scan and biochemical laboratory tests were performed for all patients at baseline and 30 days after each TACE. Image analysis included measurement of lesion diameters as well as contrast enhancement. Eleven patients deceased before completing three session and the final analyses were performed on the remaining 34 patients. Evaluation of a total 93 lesions in all patients after chemoembolization sessions revealed a 25.88% reduction in anteroposterior (AP) diameter, 33.92% transverse (T) diameter, and 42.22% in product of APxT diameter of lesions (P
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