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Efficacy of Vancoplus Against Intra Abdominal Infected Mice: A Novel Fixed Dose Combination of Ceftriaxone Plus Vancomycin

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Author(s): A. Soni | V.K. Dwivedi | M. Chaudhary

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 9;
Issue: 7;
Start page: 655;
Date: 2009;
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Keywords: Ceftriaxone-vancomycin | intra-abdominal infection | antioxidant enzymes | E. coli | malonaldialdehyde

ABSTRACT
The study was planned to monitor antioxidant and extracellular parameters on different days of interval in blood of infected and treated groups of mice during abdominal infection by treatment of ceftriaxone plus vancomycin (vancoplus). Fifty-four young Mus musculus mice were divided into three groups as follows: control group (n = 6), infected group (n = 24) and treated with CV group (n = 24). Intraperitonial injection of Escherichia coli (1x106cfu) was given for intra abdominal infection. FDC of CV was administered intravenously in the dosage of 42.8 mg kg-1 body twice daily for 7 days. The activities of antioxidant enzymes such as superoxide dismutase and catalase as well as the concentration of malonaldialdehyde, as an indicator of lipid peroxidation were measured to evaluate oxidative stress in blood. A significant increased in malonaldialdehyde, creatinine and uric acid levels (p
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