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Efficiency of different rat lines as biomodel in the chromosomal aberrations assays bone marrow cells.

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Author(s): Daniel Francisco Arencibia Arrebola | , Luis Alfredo Rosario Fernández | Yolanda Emilia Suárez Fernández | Alexis Vidal Novoa

Journal: RETEL : Revista de Toxicología en Línea
ISSN 1668-091X

Volume: 40;
Start page: 1;
Date: 2013;
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Keywords: Rats | genotoxicity | chromosomal aberrations

ABSTRACT
The aimed of this research was to compare the efficiency in terms of sensibility of different rat lines for chromosomal aberration assays. Rats of different lines (Sprague Dawley, Lewis and Wistar rats) and both sexes were used in this study. The spontaneous and induced indexes (cyclophosphamide) were evaluated according to chromosomal aberration assay of bone marrow cell. Sprague Dawley rat showed the lower spontaneous indexes and high induced indexes to the mutagen used; that allowing detecting with a narrow error margin those substances that are classified of very low genotoxicity. These results suggesting the biggest use of this line of rat on in vivo genotoxicity assay.
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