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An Efficient Procedure Based on a MW-Assisted Horner–Wadsworth-Emmons Reaction for the Synthesis of (Z)-3,3-Trisubstituted-a,b-unsaturated Esters

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Author(s): Daniela Rossi | Anna Carnevale Baraglia | Massimo Serra | Ornella Azzolina | Simona Collina

Journal: Molecules
ISSN 1420-3049

Volume: 15;
Issue: 9;
Start page: 5928;
Date: 2010;
Original page

Keywords: (Z)-3 | 3-trisubstituted α | β-unsaturated methyl esters | aryl-alkyl ketones | Horner–Wadsworth-Emmons reaction | microwave-assisted reactions

ABSTRACT
A microwave-assisted HWE olefination process of readily accessible aryl-alkyl ketones has been developed to provide a rapid access to (Z)-3,3-trisubstituted-α,β-unsaturated methyl esters, key building blocks for the synthesis of biologically active compounds.

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