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Electroacupuncture protects the brain against acute ischemic injury via up-regulation of delta-opioid receptor in rats

Author(s): Xue-song TIAN | Jing-chun GUO

Journal: Zhong Xi Yi Jie He Xue Bao
ISSN 1672-1977

Volume: 6;
Issue: 6;
Start page: 632;
Date: 2008;
Original page

Keywords: electroacupuncture | ischemic attack | transient | opioid receptor delta | rats

Objective: To explore the effect of δ-opioid receptor (DOR) in electroacupuncture (EA) protecting the brain against acute ischemic injury.Methods: Fifty-one rats were randomly divided into sham ischemia group, ischemia group, sham EA group, EA group, and EA+DOR antagonist (naltrindole) group. Transient focal cerebral ischemia (1 hour) was induced in rat brain by middle cerebral artery occlusion (MCAO) method. EA was applied on Shuigou (GV 26) and Neiguan (PC 6) for 30 min, starting immediately after the onset of reperfusion. Neurological deficit scores and volume of cerebral infarction were detected after 24-hour reperfusion. Other 12 rats were randomly divided into sham ischemia group, ischemia group, EA group and EA+naltrindole group. DOR protein expressions were assessed by Western blotting after 24-hour reperfusion. Results: In comparison with the ischemia group and sham EA group, EA significantly reduced ischemic infarction and neurological deficits (P

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