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Electrochemical detection of carbidopa using a ferrocene-modified carbon nanotube paste electrode

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Author(s): HALIMEH YAGHOUBIAN | HASSAN KARIMI-MALEH | MOHAMMAD ALI KHALILZADEH | FATEMEH KARIMI

Journal: Journal of the Serbian Chemical Society
ISSN 0352-5139

Volume: 74;
Issue: 12;
Start page: 1443;
Date: 2009;
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Keywords: carbidopa | ferrocene | carbon nanotube | modified electrode | voltammetry

ABSTRACT
A chemically modified carbon paste electrode (MCPE) containing ferrocene (FC) and carbon nanotubes (CNT) was constructed. The electrochemical behavior and stability of the MCPE were investigated by cyclic voltammetry. The electrocatalytic activity of the MCPE was investigated and it showed good characteristics for the oxidation of carbidopa (CD) in phosphate buffer solution (PBS). A linear concentration range of 5 to 600 μM CD, with a detection limit of 3.6±0.17 μM CD, was obtained. The diffusion coefficient of CD and the transfer coefficient () were also determined. The MCPE showed good reproducibility, remarkable long-term stability and especially good surface renewability by simple mechanical polishing. The results showed that this electrode could be used as an electrochemical sensor for the determination of CD in real samples, such as urine samples.

Tango Jona
Tangokurs Rapperswil-Jona

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