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Electrochemical Determination of Antihypertensive Drug Nisoldipine in Bulk and Tablet Dosage Form Using Carbon Paste Electrode

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Author(s): Ali K. Attia* Refaat A. Saber and Shabaan A. Abdulla

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 7;
Start page: 2362;
Date: 2011;
Original page

Keywords: Nisoldipine | Oxidation | Normal pulse voltammetry | Differential pulse voltammetry | Tablets.

ABSTRACT
The electrochemical behavior of nisoldipine has been carried out in Britton-Robinson buffer of pH 2.0-10.0 at carbon paste electrode; a well-defined irreversible oxidation peak was developed. Normal and differential pulse voltammetry were used to determine nisoldipine in bulk and tablets. The peak current varied linearly in the following ranges: 1.6 X 10-6-5.2 X 10-6 mol L-1 and 8.0 X 10-7- 5.6 X 10-6 mol L-1 in case of normal and differential pulse voltammetry, respectively. In case of normal pulse voltammetry the limits of detection (LOD) and quantification (LOQ) were 2.73 X 10-7 mol L-1 and 9.11 X 10-7 mol L-1, respectively. For differential pulse voltammetry the LOD and LOQ were 9.37 X 10-8 mol L-1 and 3.12 X 10-7 mol L-1, respectively. The percentage recoveries were found in the following ranges: 99.36-100.21% and 99.65-100.84% for normal and differential pulse voltammetry, respectively. The relative standard deviations were found in the following ranges: 0.375-0.877% and 0.544-1.226% in case of normal and differential pulse voltammetry, respectively.

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