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Electrophoretic Pattern of Hereditary Haemoglobin Disorders in Bangladesh

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Author(s): Md. Kazim Uddin | Md. A Aziz | Md. Fakhruddin Bhuya | Tashmim Farhana Dipta | Masuda Begum | ABM Yunus | Md. Jalilur Rahman

Journal: Medicine Today
ISSN 1810-1828

Volume: 21;
Issue: 02;
Start page: 58;
Date: 2009;
Original page

Keywords: Electrophorctic pattern | Haemoglobin disorders

ABSTRACT
Background: Genitic defects of hemoglobin are the most common genetic disorders andAffect around 7% of world population, occur in iropical and sub tropical areas. Beta-thalaraemia is more common in the Mediterranean region while Alfa –thabssaemia is more common in the far- East. Objective: To Find out the Pattern of haemoglobin disorders. Toevaluate and compare the diseases in study Population. Methosds: For this, a total number of 210 subjects with age ranged from 2 to 72 years of both sexes are included in the study. The present study was conducted in out patient department (OPD) of Haematolegy, Bangobondhu Shaikh Muzib Medical University (BSMMU) Dhaka. Bangladesh. During the Period of January2002 to December 2002, Patient ware selected on the basis of morphological blood film examination and Hb- electrophoresis on cellulose acetate at PH 8.6.Result: Among the 210 Subjects, thalassaemia Trait were (47.14%) , Hb-E-beta thalassamia ware 30.47%, Hb E Trait 13.3%, Hb E disease (5.71%) and thalasscmia major ware ( 3.33%). Conclusions: It is evident that, Hereditary Haemoglobin disorders are quite common in Bangladesh and this disorders are in jherited as autosomal dominant mendalian pattern affecting both male and female.

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