Academic Journals Database
Disseminating quality controlled scientific knowledge

Electrophysiological study of amygdale-induced changes in the excitability of CA1 hippocampal pyramidal neurons in male adult rats

ADD TO MY LIST
 
Author(s): Zohre Ghotbeddin | Javad Mirnajafi-Zadeh | Saeed Semnanian | Mahyar Janahmadi

Journal: Physiology and Pharmacology
ISSN 1735-0581

Volume: 16;
Issue: 1;
Start page: 33;
Date: 2012;
Original page

Keywords: Amygdala kindling | Seizure | Hippocampal Pyramidal Neurons | Whole Cell Patch Clamp Recoding | Inward current

ABSTRACT
Introduction: Many studies have shown that amygdala kindling produces synaptic potentiation by induction of changes in the neuronal electrophysiological properties and inward currents both in epileptic focus and in the areas which are in connection with the epileptic focus and have important role in seizure development and progression such as hippocampal CA1 region. However, cellular mechanisms of these processes are not clear. In the present study, changes in the electrophysiological properties of hippocampal CA1 pyramidal neurons following amygdala kindling were examined in rat. Methods: Animals were rapidly kindled by stimulation of right amygdala (12 stimulation per day, 1 ms pulse duration at 50Hz). Twenty-four hours after amygdala kindling, electrophysiological properties and inward currents of CA1 pyramidal neurons were assessed by using whole-cell patch clamp technique. Results: Amygdala kindling findings show that percentage broadening of the last spike compared to the first spike during a trains of action potentials was significantly increased in kindled rats (p
Why do you need a reservation system?      Save time & money - Smart Internet Solutions