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Electrophysiological Study of Sciatic Nerve Regeneration Through Tubes Seeded with Schwann Cells

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Author(s): Mehrdad Bakhtyari | Hamid Abootaleb | Korosh Mansouri

Journal: Basic and Clinical Neuroscience
ISSN 2008-126X

Volume: 1;
Issue: 3;
Start page: 49;
Date: 2010;
Original page

Keywords: Silicon tube | Schwann cells | Sciatic nerve | Regeneration | Electrophysiology | Latency | Amplitude

ABSTRACT
A B S T R A C TIntroduction: Peripheral nerve injury is a common disorder and leads to permanent neurological defects. Schwann cells have been shown to have nerve repair after being transplanted in peripheral nerve injury. The aim of this study was to determine the beneficial effect of allograft Schwann cells on electrophysiological outcome after transection of the sciatic nerve in rats.Methods: Twenty adult male Wistar rats (200-250 g) were used in this study and left sciatic nerve was cut 10 mm in all of them and randomly divided into two groups. Then, the experimental (n=10) and control (n=10) groups received silicon tube with Schwann cells and silicon tube without Schwann cells respectively. Electrophysiological studies were performed 8 weeks after transplantation. Results: Electrophysiological study in experimental animals showed that amplitude of nerve action potential is higher and latency is less as compared to the control group (p
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