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Elevated Levels of Interleukin-23 in Sera of Patients with Pemphigus Vulgaris

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Author(s): Firouz Pouralibaba | Zohreh Babaloo | Farzaneh Pakdel | Tahmoores Abdollahian | Solmaz Pourzare

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 9;
Issue: 4;
Start page: 261;
Date: 2012;
Original page

Keywords: Autoimmune Disease | Interleukin-23 | Pemphigus Vulgaris

ABSTRACT
Background: Pemphigus vulgaris, a chronic mucocutaneous disease, is the most prevalent type of pemphigus which manifests with development of bullae and erosions on skin and mucosal membranes. Objectives: To investigate the potential role of IL-23 in pemphigus vulgaris. Methods: In this study, 30 patients with pemphigus vulgaris and 30 healthy individuals were selected according to inclusion and exclusion criteria. Measurement of IL-23 serum levels in blood samples was conducted by ELISA. Data was analyzed using Student’s t-test for comparison of IL-23 levels between the two groups. Results: Mean serum levels of IL-23 in patients with pemphigus and healthy controls were 25.1 ± 4.2 and 17.9 ± 4.7 pg/ml, respectively (p

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