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Endothelium-derived markers and antioxidant status in the blood of obstructive sleep apnea males

Author(s): Cofta S | Wysocka E | Michalak S | Piorunek T | Batura-Gabryel H | Torlinski L

Journal: European Journal of Medical Research
ISSN 2047-783X

Volume: 14;
Issue: Suppl 4;
Start page: 49;
Date: 2009;
Original page

Keywords: obstructive sleep apnea | total antioxidant status | endothelium | E-selectin

Abstract Objective The relationship between obstructive sleep apnea (OSA) and cardiovascular disease is intensively discussed. Endothelial leukocyte adhesion molecule (E-selectin) is one of factors facilitating leukocyte migration to the subendothelial layer which could be considered proatherogenic. The aim of the study was to determine E-selectin levels and total plasma antioxidant status (TAS) in the blood of different stage OSA patients. Methods Non-smoking, OSA-suspected males, aged 30-63, were selected for the study. An EMBLA polysomnographic system was used to establish the severity of apneic episodes. The results of apnea/hypopnea index (AHI) allowed dividing patients into the following groups: OSA-0 with AHI 0-4.9 (n = 14), OSA-1 with AHI 5-15 (n = 14), OSA-2 with AHI 16-30 (n = 13), OSA-3 with AHI ≥ 30 (n = 13). Complete blood count (CBC), glycemia during oral glucose tolerance test, fasting plasma lipid profile, uric acid, and high sensitivity C-reactive protein (hsCRP) were estimated among routine parameters. We determined plasma concentrations of E-selectin and total antioxidant status. Results We found progressively decreasing concentrations of TAS (P = 0.03) and increased concentrations of E-selectin (P = 0.0001) from OSA-0 to OSA-3 subjects. No correlation between E-selectin and metabolic parameters was noted. Conclusion In the studied OSA groups, E-selectin appeared an independent proatherogenic factor.
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