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Enhanced Gene Expression Following Vaccination in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

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Author(s): Ekua W. Brenu | Gunn M. Atkinson | Mieke L. van Driel | Sanne Kreijkamp-Kaspers | Don R. Staines | Sonya M. Marshall-Gradisnik

Journal: International Journal of Clinical Medicine
ISSN 2158-284X

Volume: 04;
Issue: 03;
Start page: 165;
Date: 2013;
Original page

Keywords: Chronic Fatigue Syndrome | Perforin | Granzymes | Cytokines

ABSTRACT
Vaccines have been shown to cause differential expression of genes and increase antibody titers against antigens.   Influenza vaccines may have an effect on unexplained disorders such as Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). Immunological changes have been identified following immunization with trivalent influenza vaccine (TIV). The GZMB may increase the expression of lytic genes in CFS/ME and this may contribute to the increase in cytotoxic activity we observed in these patients post vaccination.
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