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ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF NEVIRAPINE BY SOLID DISPERSION TECHNIQUE USING DEXTRAN: PREPARATION AND IN VITRO EVALUATION

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Author(s): Lokamatha K. M

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 12;
Start page: 1;
Date: 2011;
Original page

Keywords: Nevirapine | Antiretroviral | Solid dispersions | Freeze drying | Dextran

ABSTRACT
Solid dispersions (SDs) of nevirapine (NVP) were prepared with the objective of dissolution enhancement by kneading and freeze drying technique using a novel carrier of low molecular weight dextran (DEX) at varied concentrations of drug: carrier (3:1 and 1:1w/w). The Fourier transform-IR (FT-IR) studies indicated the possibility of hydrogen bonding with the polymer. Powder-XRD and DSC were used to characterize the solid dispersions, indicated a transformation of drug from crystalline to microcrystalline form. In vitro dissolution studies of SDs performed in 0.1 N HCl showed a significant increase in dissolution rates of NVP comparing to physical mixtures and pure drug. Comparatively, SD of NVP:DEX, prepared by freeze drying method exhibited a higher release rate than prepared by kneading method. Improved dissolution of model drug may be attributed to the modification in drug crystallinity in SDs as was evident from our analytical studies. The dissolution pattern of the NVP from all the SDs followed predominantly first order kinetics compared to Hixson-Crowell’s cube root law. This study reflects the vital role of low molecular weight DEX as a novel carrier to improve the solubility of NVP, which could minimize the variable dissolution rates with increase in oral bioavailability.
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