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Enhancers and silencers: an integrated and simple model for their function

Author(s): Kolovos Petros | Knoch Tobias A | Grosveld Frank G | Cook Peter R | Papantonis Argyris

Journal: Epigenetics & Chromatin
ISSN 1756-8935

Volume: 5;
Issue: 1;
Start page: 1;
Date: 2012;
Original page

Keywords: enhancer | silencer | insulator | transcription factory | hub | long-range interactions | chromosome conformation capture | three-dimensional genome architecture

Abstract Regulatory DNA elements such as enhancers, silencers and insulators are embedded in metazoan genomes, and they control gene expression during development. Although they fulfil different roles, they share specific properties. Herein we discuss some examples and a parsimonious model for their function is proposed. All are transcription units that tether their target promoters close to, or distant from, transcriptional hot spots (or 'factories').

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