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Enrofloxacin drug induced reactive oxygen species

Author(s): Ishraga G. Ibrahim | Yarsan E

Journal: Research Opinions in Animal & Veterinary Sciences
ISSN 2221-1896

Volume: 1;
Issue: 8;
Start page: 489;
Date: 2011;
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Keywords: Antioxidant Enzymes | Broilers | Enrofloxacin | Malondialdehide | Reactive Oxygen Species

Fluroquinolones drugs are known to have adverse effects including chondriotoxicity, however, the mechanism of this effect was not fully understood. To investigate the possibility of the involvement of oxidative stress in this mechanism, enrofloxacin was administered orally to 80 broiler chicks for 15 and 30 days at 100, 200 and 400 mg/kg body weight and the activities of some antioxidant enzymes and malondialdehide (MDA) blood levels were studied. An increase in MDA levels and decrease in the activities of antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT) suggest that, the adverse effects of enrofloxacin might be due to oxidative stress. Our results support the hypothesis that free radical mediated reactions might be involved in the adverse reactions of fluoroquinolones.
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