Academic Journals Database
Disseminating quality controlled scientific knowledge

Entropy and Information Approaches to Genetic Diversity and its Expression: Genomic Geography

ADD TO MY LIST
 
Author(s): William B. Sherwin

Journal: Entropy
ISSN 1099-4300

Volume: 12;
Issue: 7;
Start page: 1765;
Date: 2010;
Original page

Keywords: entropy | information | genes | DNA sequence | subdivision | dispersal | migration | natural selection | genome-wide association studies | linkage disequilibrium | gene expression | gene regulation | disease phenotypes

ABSTRACT
This article highlights advantages of entropy-based genetic diversity measures, at levels from gene expression to landscapes. Shannon’s entropy-based diversity is the standard for ecological communities. The exponentials of Shannon’s and the related “mutual information” excel in their ability to express diversity intuitively, and provide a generalised method of considering microscopic behaviour to make macroscopic predictions, under given conditions. The hierarchical nature of entropy and information allows integrated modeling of diversity along one DNA sequence, and between different sequences within and among populations, species, etc. The aim is to identify the formal connections between genetic diversity and the flow of information to and from the environment.

Tango Jona
Tangokurs Rapperswil-Jona

     Save time & money - Smart Internet Solutions