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Etodolac Attenuates Hippocampal Blood Flow Responses Induced by Tooth Pulp Stimulation in Rats

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Author(s): Makoto Hasegawa | Junichi Hada | Tetsuya Abe | Nao Ohtsu | Kousuke Honda | Masahiro Urade

Journal: Neuroscience & Medicine
ISSN 2158-2912

Volume: 02;
Issue: 03;
Start page: 295;
Date: 2011;
Original page

Keywords: Cyclooxygenase-2 (COX-2) | Etodolac | Fear Memory | Hippocampal Blood Flow | Mean Arterial Blood Pressure | Tooth Pulp Stimulation

ABSTRACT
In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (MABP) and HBF in urethane-anesthetized rats using laser Doppler flowmetry and examined the effects of etodolac, a specific COX-2 inhibitor, on TPS-induced MABP and HBF responses. The MABP response was not attenuated by the intraperitoneal (i.p.) administration of etodolac (10 mg/kg); however, the HBF response was significantly attenuated by etodolac administration. These results suggest that COX-2 may be involved in the mechanisms regulating TPS-induced HBF responses.

Tango Jona
Tangokurs Rapperswil-Jona

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