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Evaluating Anti-Inflammatory activity of aqueous root extract of Strophanthus hispidus DC. (Apocynaceae)

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Author(s): E O Agbaje | M S Fageyinbo

Journal: International Journal of Applied Research in Natural Products
ISSN 1940-6223

Volume: 4;
Issue: 4;
Start page: 7;
Date: 2011;
Original page

Keywords: Oedema | Inflammation | Strophanthus hispidus | rodents

ABSTRACT
Summary: The present study explored the anti-inflammatory potential of aqueous root extract of Strophanthus hispidus (SPH) DC (Apocynaceae) in rodents, using standard laboratory models. Doses of 50, 100, 500 and 1000 mg/kg of aqueous SPH were administered orally in carrageenan-induced rat hind paw oedema, xylene-induced ear oedema in mice, and formalin-induced mice hind paw oedema (sub-acute 6 days), using indomethacin (10 mg/kg), dexamethasone 1 mg/kg and acetylsalicylic acid (Aspirin), 100 mg/kg) respectively as standard drugs. The study further explored the effect of the herbal drug on some inflammatory mediators-histamine, serotonin and prostaglandin, using only the highest dose of SPH. Results obtained showed that the extract exerted a dose-dependent and significant (p
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