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Evaluating the Effect of Aquatic Extract of Cannabis sativa Seed on Spatial Memory Consolidation in Rats

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Author(s): M. Tehranipour | S. Ebrahimpour

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 9;
Issue: 8;
Start page: 884;
Date: 2009;
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Keywords: morris water maze | spatial memory | Cannabis sativa

ABSTRACT
As the point of physiology, memory form, from changes in the conducting message in the neural webs. These changes cause to formation of long-term potentiation. Δ9-THC is Psychotropic component 4-of Cannabis sativa plant; studies show this matter can bind cannabinoid receptor in CA1 area of hippocampus. Thus the aim of this study is evaluation the effect of aquatic extraction Cannabis sativa seed on spatial 7-memory consolidation in Rats. Forty male wistar Rats (3-4 mounth, 320-260 g) were completely divided into 4 experimental groups and control group. Cannabis sativa seed was extracted with Soxhlet apparatus. To test spatial memory, Morris water mazemaze (7 days, 4 trails) was used. Experimental groups with 50, 100, 150 and 210 mg kg-1 were injected in the peritoneal (IP) and after 1 h of injection spatial memory was scaled. The result show that experimental groups (50, 100 and 150 mg kg-1 doses), for learning time have significant level deduction in the comparison of control group (p
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