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Evaluation of analgesic and antipyretic activity of ethanolic and aqueous extract of Cryptolepis buchanani leaves on experimental animal model

Author(s): Goutam Nishant1, Pawan Bajpai2*, Prem Lata1,Mahfoozur Rahman

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3070;
Date: 2011;
Original page

Keywords: cryptolepis buchanani | Analgesic activity | Antipyretic activity | Prostaglandin.

The ethanolic and aqueous extracts of cryptolepis buchanani leaves was studied for its in-vivo analgesic and antipyretic activity by using tail- immersion method,acetic acid induced writhing response, formaline-induced pain in mice and brewer’s yeast-induced pyrexia in rats respectively. The safety of extracts in animals wasconfirmed from the acute toxicity studies. The time course study was performed to find the peak time for the maximum analgesic activity. The effective dose ofthe extracts for analgesic activity was calculated from dose-response curve by using these three animal models. Both the ethanolic and aqueous extracts ofcryptolepis buchanani had significant (p
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