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Evaluation of Andrographis paniculata leaves extract for analgesic activity

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Author(s): G. Shivaprakash1, H.N. Gopalakrishna*1, Deepti Sandeep Padbidri 1, Shruthi Sadanand1, Sahu Sudhanshu Sekhar1, R.Shetty Nivedita1.

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3375;
Date: 2011;
Original page

Keywords: Analgesic | acetic acid | Andrographis paniculata | Eddy’s hotplate | writhing

ABSTRACT
Aqueous extract of Andrographis paniculata leaves was subjected to analgesic activity in animal models. Materials and Methods: The study wascarried out in male swiss albino mice weighing 25-30 gm.Analgesic activity of the aqueous extract of Andrographis paniculata leaves at doses 50,100,500mg/kg p.o was evaluated using two animal models viz.acetic acid induced writhing and Eddy’s hot plate model. Results: Aqueous extract of Andrographis paniculata(AP) at doses 100mg and 500mg/Kg p.o. significantly reduced (P
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