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Evaluation of Anti-Inflammatory Activity of Roots of Eclipta prostrata Linn. (Asteraceae)

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Author(s): Ambika Sharma *, Arun Mittal , Sushma Aggarwal , Anil K Gupta , Satish Sardana .

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 2888;
Date: 2011;
Original page

Keywords: Anti inflammatory | Eclipta prostrata Linn | Ethanolic extact | Carrageenan induced paw oedema | Formalin induced paw oedema.

ABSTRACT
Eclipta prostrata Linn. [Asteraceae] popularly known as “Bhringaraj” is a very useful medicinal plant in India. The aim of the present study was to evaluatethe anti-inflammatory activity of ethanolic extract of root part of Eclipta prostrata in rats. The anti-inflammatory activity was evaluated by employing acuteinflammatory model; Carrageenan induced paw edema and Sub-acute inflammatory model; formalin induced paw edema. The study was carried out by usingadministered dose of 200mg/kg and 400mg/kg body weight of ethanolic extract orally. The extract showed significant anti inflammatory activity as comparedto Diclofenac sodium (5mg/kg body weight) in both the models in a dose dependent manner. The percentage inhibition was calculated and compared with thestandard drug and control.

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