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Evaluation of Anti-inflammatory and Membrane stabilizing property of Ethanol Extract of Cansjera rheedii J.Gmelin (Opiliaceae)

Author(s): Varadarasou Mouttaya Mounnissamy | Subramanian Kavimani | Vaithilingam Balu | Sabarimuthu Darlin Quine

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 6;
Issue: 2;
Start page: 235;
Date: 2007;
Original page

Keywords: Cansjera rheedii | Human red blood cell membrane stabilization | Carrageenin | Acute paw edema

Cansjera rheedii is widely used as a traditional medicine for the treatment and control of a variety of human inflammatory ailments by the fishermen of Auroville. In the present study, the anti-inflammatory and membrane stabilizing property of Ethanol Extract of Cansjera rheedii J. Gmelin (EECR) was evaluated in rat using the Human Red Blood Cells (HRBC) membrane stabilization method and carrageenin-induced acute paw edema model. The extract in concentration of 6-100µg/ml showed a dose-dependent inhibition of haemolysis of erythrocytes induced by hypotonic solution. Oral pre-treatment with EECR (250mg/kg) inhibited carrageenin-induced paw edema (41.93%) within 3 hrs. It is concluded that the extract possess anti-inflammatory as well as membrane stabilizing property.

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