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EVALUATION OF ANTI-OXIDANT AND ANTI-DIABETIC ACTIVITIES OF CINNAMOMUM TAMALA LINN LEAVES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

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Author(s): Palanisamy P | K.R. Srinath | D. Yoganand Kumar | Pooja Chowdary C

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 12;
Start page: 157;
Date: 2011;
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Keywords: antidiabetic | Cinnamom tamala Linn. | anti-oxidant.

ABSTRACT
The main objective of this study was to focus on the anti-diabetic activity of Cinnamomum tamala Linn, with special reference to its curative and protective role in streptozotocin- induced diabetic animal model. Attempts were further made to study the antioxidant properties of Cinnamomum tamala Linn. leaves. The efficacy of 50% ethanolic extract of leaves of Cinnamomum tamala showed significant decrease in the blood glucose level and increase in the antioxidant efficacy in streptozotocin induced diabetes. It was demonstrated that the oral administration of the 50% ethanolic extract of leaves of Cinnamomum tamala extract to streptozotocin induced diabetic rats showed significant positive changes in the biochemical and physiological parameters related to carbohydrate, protein and lipid metabolism., the strong antihyperglycemic and the anti-oxidant effect observed in streptozotocin-induced diabetic rats justified the use of 50% ethanolic extract of leaves of Cinnamomum tamala for the treatment of diabetes-related complications.
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