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Evaluation of Anti-pyretic Potential of Ichnocarpus Frutescens Roots

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Author(s): A. Pandurangan | RL. Khosa | S. Hemalatha

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 8;
Issue: 1;
Start page: 47;
Date: 2009;
Original page

Keywords: Ichnocarpus Frutescens | Methanol Extract | Anti-Pyretic Effect

ABSTRACT
The methanol extract of Ichnocarpus frutescens R.Br. root (MEIF) was evaluated for its anti-pyretic potential on normal body temperature and yeast-induced pyrexia in albino rats. Yeast suspension (10 ml/kg body wt.) increased rectal temperature 19 h after subcutaneous injection. The MEIF, at doses of 100, 200, and 300 mg/kg body wt., p.o., produced significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose dependent manner. The effect extended up to 5 h after the drug administration. The anti-pyretic effect of MEIF was comparable to that of paracetamol (150 mg/kg body wt., p.o.), a standard anti-pyretic agent.

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