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EVALUATION OF ANTI-ULCER ACTIVITY OF METHANOLIC EXTRACT OF ANOGEISSUS LATIFOLIA LEAVES IN ALBINO RATS

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Author(s): Arutla Rajender | A. Suresh | V. Suresh | G. Saker | N. Varaprasad

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 2;
Start page: 677;
Date: 2011;
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Keywords: Anogeissus latifolia | gastric lesions | helicobacter pylori | balki | unani medicine.

ABSTRACT
Anogeissus latifolia (Roxb. ex DC.) Wall. ex Guill. & Perr. (Combretaceae) has been reported to be used in the treatment of various disorders including stomach and skin diseases. We studied the antiulcer potential of the methanolic extract in order to validate ethnobotanical claims regarding the plant use in the above-mentioned disorders. Gastroprotective potential of the methanolic extract of Anogeissus latifolia (ALE) (200 and 400 mg/kg/body weight) was studied on aspirin, and ethanol-induced ulcers. The results of the present study showed for the first time that the ALE possessed gastroprotective activity as evidenced by its significant inhibition in the formation of ulcers induced by chemical agents with a maximum of 88.95%. The parameters studied were ulcer index, gastric juice volume, pH, free acidity and total acidity. These findings could justify, at least partially, the inclusion of this plant in the management of gastric disorders in traditional medicine.

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