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EVALUATION OF ANTI-ULCER ACTIVITY OF PAEDERIA FOETIDA ROOT EXTRACTS IN EXPERIMENTALLY INDUCED GASTRIC ULCER IN RATS

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Author(s): K Srinavas Reddy | A Sanjeeva Kumar | S Ganapaty

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 5;
Start page: 1556;
Date: 2011;
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Keywords: Paederia foetida | pyloric ligation method | Aspirin induced ulcers | Ranitidine | Sucralfate.

ABSTRACT
Paederia foetida Linn., a member of Rubiaceae is an extensive climber, known as Chinese flower in English, Gandhaprasarini in Hindi, Gandha bhadulia in Bengali, Prasarani in Sanskrit and Savirela in Telugu. It is found in the Himalayas from Dehradun eastwards up to an altitude of 1800m and also in Bihar, Orissa, Bengal, Assam and Araku vally in Visakhapatnam district of Andhra Pradesh. Since the plant was reported to have many medicinal uses, we taken up the plant to give scientific support to the folklore claim on the antiulcer activity of roots. The anti ulcer screening was performed using two methods that is pyloric ligation method and aspirin induced ulcerations in rats. Volume of gastric acid, total acidity and the free acidity were also measured to assess the anti ulcer potential. The present investigation therefore expressed that the roots of P. foetida exerts anti-ulcer activity which may be due to anticipated inhibition of H2 receptors resulting in inhibition of gastric acid secretion elicited by histamine and gastrin. The work justifies its use in the traditional system of medicine.
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