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Evaluation of anti-ulcerogenic properties from the root of Flemingia strobilifera

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Author(s): Anil Kumar KV | Babul Dewan | Rama T

Journal: Journal of Basic and Clinical Pharmacy
ISSN 0976-0105

Volume: 2;
Issue: 1;
Start page: 33;
Date: 2011;
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Keywords: Flemingia strobilifera root | Antiulcer | Antioxidant | Antimicrobial.

ABSTRACT
PURPOSE: To investigate the anti-ulcerogenic properties of the chloroform extract of Flemingia strobilifera root in rats.METHODS: Anti-ulcer effect was evaluated by water immersion induced ulcer in rats.Other anti-ulcer related activities of the extract such as the effects on free radicals and antimicrobial activity were also evaluated.RESULTS: Chloroform extract of Flemingia strobilifera root was found to be safe up to 300 mg/kg body weight when administrated orally in female wistar rats. Water immersion stress produced characteristic lesions in the glandular portion of the rat stomach.Pretreatment with Chloroform extract of Flemingia strobilifera root reduced the characteristic lesions in a dose dependent manner (P
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