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EVALUATION OF ANTIBACTERIAL AND ANTICANDIDIAL EFFICACY OF AQUEOUS AND ALCOHOLIC EXTRACT OF NEEM (AZADIRACHTA INDICA) AN IN VITRO STUDY

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Author(s): Nayak Aarati | Nayak Ranganath N. | G Soumya B. | Bhat Kishore | Kudalkar Mithun

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 1;
Start page: 230;
Date: 2011;
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Keywords: Aqueous Neem extract | alcoholic neem extract | E. faecalis | S.mutans | C. Albicans | serial broth dilution | MIC.

ABSTRACT
Medicinal plants are part and parcel of humans since the dawn of civilization. In recent years, multiple drug resistance has developed due to indiscriminate use of synthetic drugs. This drives the need to screen medicinal plants for novel bioactive compounds as plant based drugs are biodegradable, safe and have fewer side effects. Neem (Azadirachta indica) is perhaps the most commonly used traditional medicinal plant of India. Almost all parts of the plant are endowed with medicinal properties. Several pharmacological activities and medicinal applications of various parts of Neem have been documented in the ancient literature. Teeth and their supporting structures are subject to infections by Streptococcus species, a number of facultative anaerobes like Enterococcus faecalis, and opportunistic pathogens like Candida albicans. Literature shows that Neem is a powerful agent that inhibits the increase and establishment of microorganisms that cause infectious diseases in the oral cavity.In the present study we have evaluated the antimicrobial potential of Neem leaf aqueous and alcohol extracts. To determine the inhibitory effect of Azadirachta indica (aqueous and alcoholic extract of neem) on Streptococcus mutans, Enterococcus faecalis and Candida albicans. The activity of Azadirachta indica against Candida albicans, Streptococcus mutans and Enterococcus faecalis was tested by serial broth dilution method and was expressed by minimum inhibitory concentration (MIC). The minimum inhibitory concentration (MIC) of the aqueous neem extract to all the organisms was 7.5%. The MIC of the alcoholic neem extract for E. faecalis, S.mutans, C. albicans were 1.88%, 7.5%, and 3.75% respectively.
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