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EVALUATION OF ANTICONVULSANT ACTIVITY OF ROOTS AND RHIZOMES OF CYPERUS ROTUNDUS LINN. IN MICE

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Author(s): Porwal Mayur | Prakash Pawan | Saxena Ashwin | Sharma Pravesh

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 10;
Start page: 37;
Date: 2011;
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Keywords: Cyperus rotundus | Benzodiazepine receptors | pentylenetetrazol | picrotoxin.

ABSTRACT
The aim of the present study was to evaluate the effects of Cyperus rotundus (CR) roots and rhizomes on seizures induced by pentylenetetrazol (PTZ) and picrotoxin (PTX). Pretreatment with hydroalcoholic extract of Cyperus rotundus (CR) roots and rhizomes (50-200mg/kg) induced a dose-dependent decrease in the incidence of both clonic and generalized tonic–clonic seizures (P≤0.05) following PTZ and PTX administration. Co-administration of a sub-effective dose of CR (50 mg/kg, po) with a sub-protective dose of diazepam (0.5 mg/kg, ip) increased the latency to seizure. The combination significantly enhanced percent protection against PTZ and PTX induced convulsions. The results suggested that the anticonvulsant effect of Cyperus rotundus (CR) roots and rhizomes against PTZ and PTX induced convulsions may be mediated, at least partly, through GABAA-benzodiazepine receptor complex.
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