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An evaluation of the antidiabetic effects of Elaeocarpus ganitrus in experimental animals

Author(s): Hule Amolkumar | Shah Abhishek | Gambhire Manoj | Juvekar Archana

Journal: Indian Journal of Pharmacology
ISSN 0253-7613

Volume: 43;
Issue: 1;
Start page: 56;
Date: 2011;
Original page

Keywords: Antihyperglycemic | diabetes | Elaeocarpus ganitrus | streptozotocin

Objective : To evaluate the antidiabetic effects of the aqueous extract of Elaeocarpus ganitrus (EAG) in experimental animals. Materials and Methods : The hypoglycemic activity of the EGA was evaluated in normoglycemic rats by single dose at three graded dose levels, viz. 250, 500 and 1000 mg/kg of body weight. Antihyperglycemic activity of the extract was also evaluated at the same dose levels in streptozotocin (STZ) (60 mg/kg, i.p.)-induced diabetic rats during a 30-day treatment period. Metformin (500 mg/kg) was used as the reference drug. Fasting blood glucose and lipid parameters, viz. triglycerides, total cholesterol, high-density lipoprotein and low-density lipoprotein levels were measured. Acute oral toxicity of the EGA extract was carried out in Swiss albino mice. Results : In normoglycemic rats, EGA showed a significant (P < 0.01) hypoglycemic effect at 2 h. In STZ-induced diabetic rats, the EGA treatment significantly (P < 0.05) decreased the blood glucose level in a dose-dependent manner during the 30 days of treatment period. EGA modulated lipid profile changes in STZ-diabetic rats in a dose-dependant manner. In the acute oral toxicity study, EGA showed no mortality till the 5 g/kg dose in mice. Conclusion : The present investigation shows that EAG seeds has potential antidiabetic effects.
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