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Evaluation of Antidiarrhoeal and Neuropharmacological Activity of Cynanchum acutum in Rat

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Author(s): Fereshteh Javadian | Zohre Ganjali | Mehdi Dehghani | Jasem Estakhr | Abbas Heidari

Journal: Asian Journal of Medical Sciences
ISSN 2040-8765

Volume: 4;
Issue: 4;
Start page: 149;
Date: 2012;
Original page

Keywords: Antidiarrhoeal | Cynanchum acutum | Neuropharmacologica

ABSTRACT
Cynanchum acutum is used in Iranian traditional medicine as an agent for treatment of some diseases and troubles. In this present study, effects of Cynanchum acutum on rat for its neuropharmacological and antidiarrhoeal activity were evaluated. One hundred and fifty mg/kg/day of Cynanchum acutum as treatment was given to 10-week old wistar rats and neuropharmacological and antidiarrhoeal properties of that were evaluated. The extract of Cynanchum acutum potentiated the pentobarbital induced sleeping time in rats and decreased the open field score in open field test, decreased the number of hole crossed from 1 chamber in the hole cross test and decreased the head dip responses in hole board test. It can be conclude that Cynanchum acutum has neuropharmacological and antidiatthoeal effects in rats.
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