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EVALUATION OF ANTIDIARRHOEAL ACTIVITY OF SIDA RHOMBIFOLIA LINN. ROOT

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Author(s): Sarangi Rashmi Ranjan | Mishra Uma Shankar | Panda Susanta Kumar | Behera Saiprasanna

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 9;
Start page: 157;
Date: 2011;
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Keywords: Sida rhombifolia | antidiarrhoeal activity | castor oil | diphenoxylate and atropine sulphate.

ABSTRACT
The roots of Sida rhombifolia are used in traditional medicine for the treatment of diarrhoea. Thus the methanolic extract of Sida rhombifolia (Malvaceae) root was investigated for its antidiarrhoeal property to substantiate folkloric claim. The methanolic extract of Sida rhombifolia, at graded dose (200 and 400 mg/kg body weight) was investigated for antidiarrhoeal activity in castor oil induced diarrhoea. Results were comparable to that of standard drug Diphenoxylate (50mg/kg body weight). A single oral dose of Sida rhombifolia extract of 400 mg/kg body weight produced a significant decrease in the severity of diarrhoea. To understand the mechanism of its antidiarrhoeal activity, its effect was further evaluated on intestinal transit and castor oil induced intestinal fluid accumulation (enteropooling). Extract produced profound decrease in intestinal transit (57.73-61.84%) and significantly inhibited castor oil induced enteropooling comparable to that of intraperitonial injection of standard drug atropine sulphate. The results showed that the methanolic extract of Sida rhombifolia have a significant antidiarrhoeal activity and supports its traditional uses in herbal medicine.
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