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Evaluation of Antioxidant, Antinociceptive Activities of Oxalis corniculata in Diabetic Neuropathy Rats

Author(s): V. Sampath Kumar | V. Venumadhav | K. Jagadeeshwar | B. Bhaskar | Mangala Lahkar

Journal: International Journal of Pharmacology
ISSN 1811-7775

Volume: 8;
Issue: 2;
Start page: 122;
Date: 2012;
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Keywords: enzymatic activity | peroxidation | Oxalis corniculata | hyperalgesia | Diabetic neuropathy

Diabetic neuropathy is damage to nerves in the body that occurs due to high blood sugar levels from diabetes. In this study we tried to evaluate the antioxidant, antinociceptive activities of ethanolic extract of Oxalis corniculata in experimentally induced diabetic rats. At the end of the 5th week, Diabetic rats were showed significant reduction in tail flick latency by 49% in hot water tail immersion test and decreased paw withdrawal response by 47% in hot plate test. Treatment with extract (400 mg kg-1) was showed a significant increase in reduced glutathione (GSH) levels. After 4 weeks treatment with extract was showed significantly increase in Superoxide dismutase (SOD) activity, treatment with extract 200 mg kg-1 and 400 mg kg-1 significantly decrease in catalase activity, MDA and significant reduction as dose dependant manner in plasma nitrite levels in diabetic rats.

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