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Evaluation of Antiserotonergic Activity of Ethyl Acetate Extract of Abrus precatorius Leaves

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Author(s): Amol B. Choudhari*, Sayyed Nazim, Ashish S. Khairnar, Pravin V. Gomase, Shaikh Afsar.

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 3;
Start page: 570;
Date: 2011;
Original page

Keywords: Antiserotonergic activity | Abrus precatorius | sumatriptan.

ABSTRACT
The aim of the study is to evaluate antiserotonergic activity of ethyl acetate extract of Abrus precatorius leaves on a frog fundus strip by using sumatriptan as a standard. This plant also use as a Abortifacient, Anodyne, Aphrodisiac, Antimicrobial, Diuretic, Emetic, Expectorant, Febrifuge, Hemostat, Laxative, Purgative, Refrigerant, Sedative, Vermifuge. Studies of twins indicate a 60 to 65 percent genetic influence upon their propensity to develop migraine headache. Moreover, fluctuating hormone levels indicate a migraine relation: 75 percent of adult patients are women, although migraine affects approximately equal numbers of prepubescent boys and girls; propensity to migraine headache is known to disappear duringpregnancy, although in some women migraines may become more frequent during pregnancy. The leaves of Abrus precatorius is on soxhlet extraction with ethyl acetate shown presence of Alkaloids, Carbohydrate, Proteins, Tannins, Saponins and Amino acids and Antiserotonergic activity on frog fundus strip shown (Graded dose response) contraction in a dose of 4.25 mg and 8.25 mg on comparison with sumatriptan as a standard .
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