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Evaluation of anxiolytic activity of aqueous and alcoholic extracts of leaves of Crataegus oxycantha in mice

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Author(s): Arora Ankitkumar | M. Ashok | M. Veera Jyothsna | B. Radhakrishna | K.P. ShivalingeGowda

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 02;
Issue: 03;
Start page: 86;
Date: 2011;
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Keywords: Anxiolytic | Crataegusoxycantha | Elevated plus maze | Light dark test | Actophotometer | GABA

ABSTRACT
Crataegus oxycantha leaves have been used traditionally for the treatment of anxiety disorders. However, no systematic study was carried out on the leaf extracts for anxiolytic activity. Hence the present study was under taken for the evaluation of anxiolytic activity of ethanolic (EELCO) leaf extracts of Crataegus oxycantha in mice. The behavioral tests were conducted with treatment schedule of 1, 7 and 14 days of EELCO at 300 and 600mg/kg in comparison with diazepam 2 mg/kg in mice using elevated plus maze test(EPM), light-dark transition test(LDT), actophotometer. In EPM, there is significant increase in open arm entries and time spent in open arm in mice treated at 600 mg/kg of EELCO on 1st day, at 300 and 600 mg/kg of EELCO on 7th day and at 300 and 600 mg/kg on 14th day of EELCO. In LDT, there is significant increase in time spent in light zone in mice treated at 300 and 600 mg/kg of EELCO on 1st day, and at 300 mg/kg of EELCO on 14th day. In actophotometer model, there is significant decrease in locomotor activity in mice treated with 600 mg/kg of EELCO on 1st day and 7th day, at 300 and 600 mg/kg of EELCO on 14th day of treatment.Results indicated that EELCO at both 300 and 600 mg/kg possess anxiolytic activity with possible involvement of GABA mechanism.
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