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EVALUATION OF COGNITIVE ENHANCING ACTIVITY OF MIMUSOPS ELENGI LINN ON ALBINO RATS

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Author(s): Hadaginhal R V | Tikare V P | Patil K S | Bhanushali M D | Desai N S | Karigar A

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 1;
Issue: 2;
Start page: 484;
Date: 2010;
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Keywords: Mimusops elengi Linn | Phytochemical | cognitive enhancing activity | MES | scopolamine | acetylcholinesterase.

ABSTRACT
In the present study, flowers of Mimusops elengi Linn (Sapotacae) commonly known as Bakul was selected for preliminary phytochemical investigation and pharmacological screening of cognitive enhancing activity. The shade dried flowers were subjected to successive solvent extraction with 70 % ethanol. The extracts revealed the presence of carbohydrates, steroids, cardiac glycosides, terpenoids, flavonoids and alkaloids when subjected to chemical tests. TLC was run for their confirmation of terpenoids in Mimusops elengi Linn and then subjected to isolation by preparative TLC method and analyzed by UV, FTIR and HPTLC. In the pharmacological screening, the alcoholic extract was used for the evaluation of cognitive enhancing activity using elevated plus maza & passive avoidance task method with Mentat as Standard by using parameters of step down and transfer latency. Induction was carried out by MES and scopolamine for 7 days. On 7th day the brain was isolated for evaluation of acetylcholinesterase enzyme activity. The alcoholic extracts (200mg/kg.B.W) showed significant effect when compare to control, there was significant increase in step down latency and decrease in the of transfers latency and also decrease in acetylcholinesterase enzyme activity but was not as effective as that of standard drug. Hence it can by conclude that the flowers of Mimusops elengi Linn contain triterpenoid and hence possess significant cognitive enhancing activity.
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