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EVALUATION OF COGNITIVE ENHANCING ACTIVITY OF VITIS VINIFERA LINN. ON ALBINO RATS

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Author(s): Tikare V P | Hadaginhal R V | Raghavendra M M A V

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 4;
Start page: 154;
Date: 2011;
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Keywords: Vitis vinifera Linn | Scopolamine | Acetylcholinesterase.

ABSTRACT
In the present study fruits of Vitis vinifera Linn. (Vitacae) commonly known as Draksh were selected for preliminary phytochemical investigation and pharmacological screening of cognitive enhancing activity. The shade dried fruits were subjected to successive solvent extraction with 70 % ethanol. The extracts revealed the presence of carbohydrates, proteins, cardiac glycosides, alkaloids and flavonoids when subjected to chemical tests. TLC was run for their confirmation of flavonoids in Vitis vinifera and than subjected to isolation by preparative TLC method and analyzed by UV, FTIR and HPTLC. In the pharmacological screening, the alcoholic extract was used for the evaluation of cognitive enhancing activity using elevated plus maze & passive avoidance task method with Mentat as Standard by using parameters of step down and transfer latency. Induction was carried out by MES and scopolamine for 7 days. On 7th day the brain was isolated for evaluation of Acetylcholinesterase enzyme activity. The alcoholic extracts (200mg/kg.B.W) showed significant effect when compare to control, there was significant increase in step down latency and decrease in the transfers latency and also decrease in acetylcholinesterase enzyme activity, which was as effective as that of standard drug. Hence it can by conclude that fruits of Vitis vinifera contain favonoid and hence possess significant cognitive enhancing activity.
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